Single Molecule Studies on G-Quadruplex, Protein, and Small Molecule Interactions
نویسندگان
چکیده
منابع مشابه
A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.
Ligands that stabilize the formation of telomeric DNA G-quadruplexes have potential as cancer treatments, because the G-quadruplex structure cannot be extended by telomerase, an enzyme over-expressed in many cancer cells. Understanding the kinetic, thermodynamic and mechanical properties of small-molecule binding to these structures is therefore important, but classical ensemble assays are unab...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.11.940